Founded in 1946, Ohio University Zanesville was one of the first regional campuses established in the state. The campus of Ohio University is located on 179 acres just northwest of Zanesville on Ohio Route 146. Zanesville is 55 miles east of Columbus and 55 miles north of Ohio University's residential campus in Athens. Ohio University Zanesville functions as a cultural and educational center for the Muskingum Valley region. It enjoys strong community involvement and support.
The campus features a library, cafeteria, Campus Center, 300-seat auditorium, Learning Advancement Center, gymnasium, and state-of-the-art classrooms and labs. Some of the facilities are shared with Zane State College, in a cooperative agreement that is a model for other communities. Students can commute from home or live in privately owned apartments, some within walking distance of campus. The YWCA runs a fitness center on the campus.